Recent publications
2025
An IL-6 promoter variant (-174 G/C) augments IL-6 production and alters skeletal muscle transcription in response to exercise in mice. Watson LE, MacRae CL, Kallingappa P, Cao Y, Li X, Hedges CP, D’Souza RF, Fleming N, Mellor KM, Merry TL. J Appl Physiol (1985). 2025, 138(1):213-225. doi: 10.1152/japplphysiol.00391.2024.
2024
Mechanical loading reveals an intrinsic cardiomyocyte stiffness contribution to diastolic dysfunction in murine cardiometabolic disease. Janssens JV, Raaijmakers AJA, Koutsifeli P, Weeks KL, Bell JR, Van Eyk JE, Curl CL, Mellor KM and Delbridge LMD. J Physiol 2024, 602(24):6705-6727. DOI: 10.1113/JP286437
Methods for detection of cardiac glycogen-autophagy. Koutsifeli P, Daniels LJ, Neale J, Fong S, Varma U, Annandale M, Li X, Nursalim Y, Bell JR, Weeks KL, Stotland A, Taylor DJ, Gottlieb RA, Delbridge LMD, Mellor KM. Autophagy Reports 2024, In Press. DOI: 10.1101/2024.08.11.607511
James SL, Koutsifeli P, D’Souza RF, Masson SWC, Woodhead JST, Merry TL, Delbridge LMD, Mellor KM. Glycophagy is involved in cardiac glycogen regulation in response to exercise. Current Research in Physiology 2024 7:100131. DOI: 10.1016/j.crphys.2024.100131
Myocardial glycophagy flux dysregulation and glycogen accumulation characterize diabetic cardiomyopathy. Mellor KM, Varma U, Koutsifeli P, Daniels LJ, Benson VL, Annandale M, Li X, Nursalim Y, Janssens JV, Weeks KL, Powell KL, O’Brien TJ, Katare R, Ritchie RH, Bell JR, Gottlieb RA, Delbridge LMD. Journal of Molecular & Cellular Cardiology 2024 In press. DOI: 10.1016/j.yjmcc.2024.02.009
The cardiomyocyte origins of diastolic dysfunction: cellular components of myocardial “stiffness”. Janssens JV, Raaijmakers AJA, Weeks KL, Bell JR, Mellor KM, Curl CL, Delbridge LMD. Am J Physiol Heart Circ Physiol. 2024 326(3):H584-H598. doi: 10.1152/ajpheart.00334.2023.
A gene therapy targeting medium-chain acyl-CoA dehydrogenase (MCAD) did not protect against diabetic cardiac pathology. Weeks KL, Kiriazis H, Wadley GD, Masterman EI, Sergienko NM, Raiijmakers AJA, Trewin AJ, Harmawan CA, Yildiz GS, Liu Y, Drew BG, Gregorevic P, Delbridge LMD, McMullen JR, Bernardo BC. J Mol Med. 2024 102(1):95-111. doi: 10.1007/s00109-023-02397-2.
2023
Localized cardiomyocyte lipid accumulation is associated with slowed epicardial conduction in rats. Wells SP, Raaijmakers AJA, Curl CL, O’Shea C, Hayes S, Mellor KM, Kalman JM, Kirchhof P, Pavlovic D, Delbridge LMD, Bell JR. J Gen Physiol 2023 Nov 6;155(11):e202213296. doi: 10.1085/jgp.202213296.
Myocardial deformation imaging by 2D speckle tracking echocardiography for assessment of diastolic dysfunction in murine cardiopathology. Daniels LJ, Macindoe C, Koutsifeli P, Annandale M, James SL, Watson LE, Coffey S, Raaijmakers AJA, Weeks KL, Bell JR, Janssens JV, Curl CL, Delbridge LMD, Mellor KM. Sci Rep. 2023 Jul 31;13(1):12344. doi: 10.1038/s41598-023-39499-3.
Cellular mechanisms mediating exercise-induced protection against cardiotoxic anthracycline cancer therapy. Dozic S, Howden EJ, Bell JR, Mellor KM, Delbridge LMD, Weeks KL. Cells. 2023 May 4;12(9):1312. doi: 10.3390/cells12091312.
Regulation of mitochondrial calcium uniporter expression and calcium-dependent cell signaling by lncRNA Tug1 in cardiomyocytes. Trewin AJ, Weeks KL, Wadley GD, Lamon S. Am J Phyiol Cell Physiol. 2023 Oct 1;325(4):C1097-C1105. doi: 10.1152/ajpcell.00339.2023
2022
HFpEF etiology - Can focus on sex-specific mechanisms deliver insights for all? Delbridge LMD, Bell JR, Weeks KL, Raaijmakers AJA, Mellor KM. J Mol Cell Cardiol. 2022 Dec;173:71-72. doi: 10.1016/j.yjmcc.2022.09.005.
The big picture: cardiac sex-age interactions and proteogenomic insights. Janssens JV, Bell JR, Weeks KL, Mellor KM, Delbridge LMD. Am J Physiol Heart Circ Physiol. 2022 Oct 1;323(4):H640-H642. doi: 10.1152/ajpheart.00418.2022.
New Perspectives on Sex Steroid and Mineralocorticoid Receptor Signaling in Cardiac Ischemic Injury. Bienvenu LA, Bell JR, Weeks KL, Delbridge LMD, Young MJ. Front Physiol. 2022 Jun 29;13:896425. doi: 10.3389/fphys.2022.896425.
Glycogen-autophagy: Molecular machinery and cellular mechanisms of glycophagy. Koutsifeli P, Varma U, Daniels LJ, Annandale M, Li X, Neale JPH, Hayes S, Weeks KL, James S, Delbridge LMD, Mellor KM. J Biol Chem. 2022 Jul;298(7):102093. doi: 10.1016/j.jbc.2022.102093.
Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities. Sergienko NM, Donner DG, Delbridge LMD, McMullen JR, Weeks KL. Cell Signal. 2022 Mar;91:110213. doi: 10.1016/j.cellsig.2021.110213.
Maternal obesity: influencing the heart right from the start. Sergienko NM, Bell JR, Weeks KL. J Physiol. 2022 Jul;600(13):3007-3008. doi: 10.1113/JP283190.
2021
Fructose Metabolism and Cardiac Metabolic Stress. Annandale M, Daniels LJ, Li X, Neale JPH, Chau AHL, Ambalawanar HA, James SL, Koutsifeli P, Delbridge LMD, Mellor KM. Front Pharmacol. 2021 Jun 29;12:695486. doi: 10.3389/fphar.2021.695486.
Cardiac mechanical efficiency is preserved in primary cardiac hypertrophy despite impaired mechanical function. Han JC, Tran K, Crossman DJ, Curl CL, Koutsifeli P, Neale JPH, Li X, Harrap SB, Taberner AJ, Delbridge LMD, Loiselle DS, Mellor KM. J Gen Physiol. 2021 Aug 2;153(8):e202012841. doi: 10.1085/jgp.202012841.
Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor. Sim CB, Phipson B, Ziemann M, Rafehi H, Mills RJ, Watt KI, Abu-Bonsrah KD, Kalathur RKR, Voges HK, Dinh DT, Ter Huurne M, Vivien CJ, Kaspi A, Kaipananickal H, Hidalgo A, Delbridge LMD, Robker RL, Gregorevic P, Dos Remedios CG, Lal S, Piers AT, Konstantinov IE, Elliott DA, El-Osta A, Oshlack A, Hudson JE, Porrello ER. Circulation. 2021 Apr 20;143(16):1614-1628. doi: 10.1161/CIRCULATIONAHA.120.051921.
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Klionsky DJ, ..... Delbridge LMD..... et al.... See abstract for full author list ➔ Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280.
Elevated myocardial fructose and sorbitol levels are associated with diastolic dysfunction in diabetic patients, and cardiomyocyte lipid inclusions in vitro. Daniels LJ, Annandale M, Koutsifeli P, Li X, Bussey CT, van Hout I, Bunton RW, Davis PJ, Coffey S, Katare R, Lamberts RR, Delbridge LMD, Mellor KM. Nutr Diabetes. 2021 Feb 8;11(1):8. doi: 10.1038/s41387-021-00150-7.
Systematic quantification of histologic ventricular fibrosis in isolated mitral valve prolapse and sudden cardiac death. Han HC, Parsons SA, Curl CL, Teh AW, Raaijmakers AJA, Koshy AN, Leong T, Burrell LM, O'Donnell D, Vohra JK, Kalman JM, Sanders P, Hare DL, Farouque O, Delbridge LMD, Lim HS. Heart Rhythm. 2021 Apr;18(4):570-576. doi: 10.1016/j.hrthm.2020.12.021.